Dr. M.B. Wyatt contracted the flue, and died October 22, 1918; he had the rank of lieutenant, and had received orders to report to the war area shortly before he passed away. Dr. O.W. Wyatt then moved into the upstairs rooms of the Schelldorf block, where Miss Amanda Sievers was his nurse and Tress Sievers was an aide.

In 1926, he erected the Wyatt Memorial Hospital on Main Street. He directed this institution alone until 1930, when Dr. Merlin Wyatt, his son, became associated with him. Dr. Merlin Wyatt was called into the army in 1942, shortly after his father's death February 3, 1942. Dr. Morton, a retired physician, volunteered to return to practice and was assigned to Manning. Dr. Morton first located upstairs in the Mueller building, and later practiced through the Wyatt Memorial Hospital. He stayed in Manning until 1952.

Doctors Carl Waterbury, R.B. Anderson, and Laurel Dietrick opened their practice at the Wyatt Memorial Hospital September 15, 1945. It was a difficult time, with the second World War resulting in a scarcity of nurses and essential medical treatments. Dr. Dietrick stayed seven months and re-entered general practice. Doctors Anderson and Waterbury operated the hospital on a partnership basis for three years and five months, at which time Dr. Waterbury moved to Des Moines to establish an obstetrical practice. It was found necessary to incorporate the hospital with the people of the community and the staff.